Three dimensional structure of the anthrax toxin translocon-lethal factor complex by cryo-electron microscopy.

@article{Gogol2013ThreeDS,
  title={Three dimensional structure of the anthrax toxin translocon-lethal factor complex by cryo-electron microscopy.},
  author={Edward P. Gogol and Narahari Akkaladevi and Leszek Szerszen and Sourav Mukherjee and Lynn Chollet-Hinton and Hiroo Katayama and Bradley L Pentelute and Robert J. Collier and Mark Thomas Fisher},
  journal={Protein science : a publication of the Protein Society},
  year={2013},
  volume={22 5},
  pages={
          586-94
        }
}
We have visualized by cryo-electron microscopy (cryo-EM) the complex of the anthrax protective antigen (PA) translocon and the N-terminal domain of anthrax lethal factor (LF(N) inserted into a nanodisc model lipid bilayer. We have determined the structure of this complex at a nominal resolution of 16 Å by single-particle analysis and three-dimensional reconstruction. Consistent with our previous analysis of negatively stained unliganded PA, the translocon comprises a globular structure (cap… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Similar Papers

Loading similar papers…