Three-dimensional structure of respiratory complex I from Escherichia coli in ice in the presence of nucleotides.

@article{Morgan2008ThreedimensionalSO,
  title={Three-dimensional structure of respiratory complex I from Escherichia coli in ice in the presence of nucleotides.},
  author={David J Morgan and Leonid A. Sazanov},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1777 7-8},
  pages={711-8}
}
Complex I (NADH:ubiquinone oxidoreductase) is the largest protein complex of bacterial and mitochondrial respiratory chains. The first three-dimensional structure of bacterial complex I in vitrified ice was determined by electron cryo-microscopy and single particle analysis. The structure of the Escherichia coli enzyme incubated with either NAD(+) (as a reference) or NADH was calculated to 35 and 39 A resolution, respectively. The X-ray structure of the peripheral arm of Thermus thermophilus… CONTINUE READING

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A Structural Perspective on Respiratory Complex I

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