Three-dimensional structure of human voltage-gated ion channel Kv10.2 studied by electron microscopy of macromolecules and molecular modeling

Three-dimensional structure of the human voltage-gated channel Kv10.2 has been elucidated for the first time using the method of electron microscopy with 2.5 nm resolution. The molecule has a distinct domain structure. For interpretation of the structure, homology modeling was used with the cAMP-dependent channel MlotiK1 (C-subunit) structure used as a… (More)