Three-dimensional structure of cytoplasmic dynein bound to microtubules.

  title={Three-dimensional structure of cytoplasmic dynein bound to microtubules.},
  author={Naoko Mizuno and Akihiro Narita and Takahide Kon and Kazuo Sutoh and Masahide Kikkawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 52},
Cytoplasmic dynein is a large, microtubule-dependent molecular motor (1.2 MDa). Although the structure of dynein by itself has been characterized, its conformation in complex with microtubules is still unknown. Here, we used cryoelectron microscopy (cryo-EM) to visualize the interaction between dynein and microtubules. Most dynein molecules in the nucleotide-free state are bound to the microtubule in a defined conformation and orientation. A 3D image reconstruction revealed that dynein's head… CONTINUE READING


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