Three-dimensional structure of an antigen–antibody complex at 6 Å resolution

  title={Three-dimensional structure of an antigen–antibody complex at 6 Å resolution},
  author={A. G. Amit and Roy A. Mariuzza and Simon E V Phillips and Roberto J. Poljak},
Present understanding of the three-dimensional structure of antibody combining sites is based on X-ray diffraction studies of myeloma immunoglobulins (reviewed in refs 1, 2). The structures of the antigen-binding fragment (Fab) complexes of two of these immunoglobulins with small ligands have also been determined3,4. However, there is no crystallographic information concerning the interactions of an antibody with an antigen, nor do we know the precise structure of antigenic determinants on… CONTINUE READING

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