Three-dimensional structure of a genetically engineered variant of porcine growth hormone.

@article{AbdelMeguid1987ThreedimensionalSO,
  title={Three-dimensional structure of a genetically engineered variant of porcine growth hormone.},
  author={Sherin S. Abdel-Meguid and H. S. Shieh and W Wendell Smith and H. E. Dayringer and Bernard N Violand and L A Bentle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 18},
  pages={6434-7}
}
The three-dimensional structure of a genetically engineered variant of porcine growth hormone, methionyl porcine somatotropin (MPS), has been determined at 2.8-A resolution, using single crystal x-ray diffraction techniques. Phases were obtained by use of a single isomorphous K2OsCl6 derivative and were improved by use of the density modification procedure. The MPS structure is predominantly helical. It consists mainly of four antiparallel alpha-helices arranged in a left twisted helical bundle… CONTINUE READING

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