Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

@article{Rosenberg2005ThreedimensionalSO,
  title={Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.},
  author={Mark F. Rosenberg and Richard Callaghan and Szabolcs Modok and Christopher F. Higgins and Robert Curtis Ford},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 4},
  pages={2857-62}
}
Multidrug resistance of cancer cells and pathogens is a serious clinical problem. A major factor contributing to drug resistance in cancer is the over-expression of P-glycoprotein, a plasma membrane ATP-binding cassette (ABC) drug efflux pump. Three-dimensional structural data with a resolution limit of approximately 8 A have been obtained from two-dimensional crystals of P-glycoprotein trapped in the nucleotide-bound state. Each of the two transmembrane domains of P-glycoprotein consists of… CONTINUE READING

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