Three-dimensional structure of AAA ATPase Vps4: advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding.

@article{Landsberg2009ThreedimensionalSO,
  title={Three-dimensional structure of AAA ATPase Vps4: advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding.},
  author={Michael John Landsberg and Parimala Rao Vajjhala and Rosalba Rothnagel and Alan L. Munn and Ben Hankamer},
  journal={Structure},
  year={2009},
  volume={17 3},
  pages={
          427-37
        }
}
Vps4 is a AAA ATPase that mediates endosomal membrane protein sorting. It is also a host factor hijacked by a diverse set of clinically important viruses, including HIV and Ebola, to facilitate viral budding. Here we present the three-dimensional structure of the hydrolysis-defective Vps4p(E233Q) mutant. Single-particle analysis, multiangle laser light scattering, and the docking of independently determined atomic models of Vps4 monomers reveal a complex with C6 point symmetry, distinguishing… CONTINUE READING
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