Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemia.

@article{Krupinski2003ThreedimensionalSA,
  title={Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemia.},
  author={Jerzy Krupinski and Paul Stroemer and Mark Slevin and Eul{\`a}lia Mart{\'i} and P. R. Srikanta Kumar and Francisco Rubio},
  journal={Neuroreport},
  year={2003},
  volume={14 8},
  pages={1171-6}
}
Penumbra tissue becomes highly angiogenic after ischaemic stroke in man, and the re-establishment of a functional vasculature might be beneficial to patients. Unilateral ischaemia was induced in male Sprague-Dawley rats by permanent occlusion of the distal left middle cerebral artery (MCAO). Animals with stroke were kept alive for 1, 7, 14, 21 or 28 days after which time they were terminally anaesthetized. Vascular casts of infarcted areas, analyzed by scanning electron microscopy demonstrated… CONTINUE READING