Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator

  title={Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator},
  author={D. Venkateswarlu and S. Krishnaswamy and T. Darden and L. Pedersen},
  journal={Molecular modeling annual},
Abstract. Trocarin belongs to group D of prothrombin activators derived from snake venom of Tropidechis carinatus and is a rich non-hepatic source of Xa, the only known hepatic prothrombin activator. The structural and functional similarity with Xa makes trocarin an interesting target for exploring the structure–functional relationship with Xa. Herein we report a predicted complete three-dimensional all-atom structural model of trocarin equilibrated in explicit water using 4 ns of molecular… Expand
5 Citations
The intriguing world of prothrombin activators from snake venom.
  • R. Kini
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2005
This review provides a detailed description of the current knowledge on all prothrombin activators and highlights several intriguing questions that are yet to be answered. Expand
An all‐atom solution‐equilibrated model for human extrinsic blood coagulation complex (sTF–VIIa–Xa): a protein–protein docking and molecular dynamics refinement study
This model characterizes likely enzyme‐binding exosites on FVIIa and Xa that may be involved in the ternary complex formation and may serve as a reasonable structural basis for understanding the exosite‐mediated substrate recognition of sTF– VIIa and to advance understanding of the TFPI‐mediated regulatory pathway of the extrinsic blood coagulation cascade. Expand
Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application.
Examples of snake venom components which have spurred the development of novel pharmaceutical compounds are given, especially in the fields of hemostasis, thrombosis, coagulation, and metastasis, to help in influencing a specific body function pharmaceutically. Expand
Snake venoms and hemostasis
Snake venoms are complex mixtures of biologically active proteins and peptides that act selectively on different blood coagulation factors, blood cells or tissues. Expand
Australian Snakebite and Treatment


Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
We demonstrate in this work that the surface tension, water‐organic solvent, transfer‐free energies and the thermodynamics of melting of linear alkanes provide fundamental insights into the nonpolarExpand
Prothrombinase assembly and / or S 1 site occupation changes the zymogenlike conformation of FXa induced by mutation at the Na +binding site
  • 2001
Purification and characterization of the Prothrombin activator of the venom of Pseudonaja textiles
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