Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator

@article{Venkateswarlu2002ThreedimensionalSS,
  title={Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator},
  author={D. Venkateswarlu and S. Krishnaswamy and T. Darden and L. Pedersen},
  journal={Molecular modeling annual},
  year={2002},
  volume={8},
  pages={302-313}
}
Abstract. Trocarin belongs to group D of prothrombin activators derived from snake venom of Tropidechis carinatus and is a rich non-hepatic source of Xa, the only known hepatic prothrombin activator. The structural and functional similarity with Xa makes trocarin an interesting target for exploring the structure–functional relationship with Xa. Herein we report a predicted complete three-dimensional all-atom structural model of trocarin equilibrated in explicit water using 4 ns of molecular… Expand
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References

SHOWING 1-3 OF 3 REFERENCES
Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
We demonstrate in this work that the surface tension, water‐organic solvent, transfer‐free energies and the thermodynamics of melting of linear alkanes provide fundamental insights into the nonpolarExpand
Prothrombinase assembly and / or S 1 site occupation changes the zymogenlike conformation of FXa induced by mutation at the Na +binding site
  • 2001
Purification and characterization of the Prothrombin activator of the venom of Pseudonaja textiles
  • 1987