Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system.

@article{Eschenhagen1997ThreedimensionalRO,
  title={Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system.},
  author={Thomas Eschenhagen and Chester Fink and Ute Remmers and Holger Scholz and Jens Wattchow and Joachim Weil and W. Zimmermann and Hans-Josef Dohmen and Heiner Sch{\"a}fer and Nanette Hahr Bishopric and Tetsuro Wakatsuki and Elliot L. Elson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1997},
  volume={11 8},
  pages={683-94}
}
A method has been developed for culturing cardiac myocytes in a collagen matrix to produce a coherently contracting 3-dimensional model heart tissue that allows direct measurement of isometric contractile force. Embryonic chick cardiomyocytes were mixed with collagen solution and allowed to gel between two Velcro-coated glass tubes. During culture, the cardiomyocytes formed spontaneously beating cardiac myocyte-populated matrices (CMPMs) anchored at opposite ends to the Velcro-covered tubes… CONTINUE READING
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