Three-dimensional quantitative analysis of chromosomes in the oocytes of aging mice during meiosis I in vitro.

Abstract

The mechanism of senescence is very complicated and can involve formation of chromosome abnormalities and a decline in female fertility. In this study, 3-D visualization of fluorescently labeled chromosomes in oocytes from aging and pubertal mice during in vitro maturation was done with a two-photon laser scanning microscope. Differences between aging and… (More)
DOI: 10.1016/j.theriogenology.2012.08.010

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