Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis

  title={Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis},
  author={Thomas P. Lozito and Peter G. Alexander and Hang Lin and Riccardo Gottardi and Anthony Wai-Ming Cheng and Rocky S Tuan},
  booktitle={Stem Cell Research & Therapy},
Osteoarthritis (OA), the most prevalent form of arthritis, affects up to 15% of the adult population and is principally characterized by degeneration of the articular cartilage component of the joint, often with accompanying subchondral bone lesions. Understanding the mechanisms underlying the pathogenesis of OA is important for the rational development of disease-modifying OA drugs. While most studies on OA have focused on the investigation of either the cartilage or the bone component of the… CONTINUE READING
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