Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis

@inproceedings{Lozito2013ThreedimensionalOM,
  title={Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis},
  author={Thomas P. Lozito and Peter G. Alexander and Hang Lin and Riccardo Gottardi and Anthony Wai-Ming Cheng and Rocky S Tuan},
  booktitle={Stem Cell Research & Therapy},
  year={2013}
}
Osteoarthritis (OA), the most prevalent form of arthritis, affects up to 15% of the adult population and is principally characterized by degeneration of the articular cartilage component of the joint, often with accompanying subchondral bone lesions. Understanding the mechanisms underlying the pathogenesis of OA is important for the rational development of disease-modifying OA drugs. While most studies on OA have focused on the investigation of either the cartilage or the bone component of the… CONTINUE READING
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References

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Showing 1-10 of 44 references

Anabolic/Catabolic balance in pathogenesis of osteoarthritis: identifying molecular targets.

PM & R : the journal of injury, function, and rehabilitation • 2011
View 1 Excerpt

BP: In vitro generation of an osteochondral interface from mesenchymal stem cell–collagen microspheres

HW Cheng, KD Lu k, KM Cheung, Chan
Biomaterials • 2011
View 1 Excerpt

The role of the cartilage matrix in osteoarthritis

Nature Reviews Rheumatology • 2011
View 1 Excerpt

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