Three dimensional models of Cu(2+)-Aβ(1-16) complexes from computational approaches.

@article{AlTorres2011ThreeDM,
  title={Three dimensional models of Cu(2+)-Aβ(1-16) complexes from computational approaches.},
  author={Jorge Al{\'i}-Torres and Jean-Didier Mar{\'e}chal and Lu{\'i}s Rodr{\'i}guez-Santiago and Mariona Sodupe},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 38},
  pages={
          15008-14
        }
}
Elucidation of the coordination of metal ions to Aβ is essential to understand their role in its aggregation and to rationally design new chelators with potential therapeutic applications in Alzheimer disease. Because of that, in the last 10 years several studies have focused their attention in determining the coordination properties of Cu(2+) interacting with Aβ. However, more important than characterizing the first coordination sphere of the metal is the determination of the whole Cu(2+)-A… CONTINUE READING
BETA
1
Twitter Mention

Similar Papers

Figures, Tables, and Topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED