Three-dimensional modeling of ovarian cancer.

  title={Three-dimensional modeling of ovarian cancer.},
  author={Erin A. White and Hilary A Kenny and Ernst Lengyel},
  journal={Advanced drug delivery reviews},
New models for epithelial ovarian cancer initiation and metastasis are required to obtain a mechanistic understanding of the disease and to develop new therapeutics. Modeling ovarian cancer however is challenging as a result of the genetic heterogeneity of the malignancy, the diverse pathology, the limited availability of human tissue for research, the atypical mechanisms of metastasis, and because the origin is unclear. Insights into the origin of high-grade serous ovarian carcinomas and… CONTINUE READING

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