Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding.

@article{Sheng2009ThreedimensionalMO,
  title={Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding.},
  author={Chunquan Sheng and Zhenyuan Miao and Haitao Ji and Jianzhong Yao and Wenya Wang and Xiaoying Che and Guoqiang Dong and Jiaguo L{\"u} and Wei Guo and Wannian Zhang},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 8},
  pages={3487-95}
}
Cryptococcus neoformans is one of the most important causes of life-threatening fungal infections in immunocompromised patients. Lanosterol 14 alpha-demethylase (CYP51) is the target of azole antifungal agents. This study describes, for the first time, the 3-dimensional model of CYP51 from Cryptococcus neoformans (CnCYP51). The model was further refined by energy minimization and molecular-dynamics simulations. The active site of CnCYP51 was well characterized by multiple-copy simultaneous… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Novel mutations in CYP51B from Penicillium digitatum involved in prochloraz resistance

Journal of Microbiology • 2014
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…