Three-dimensional model of angiogenesis: coculture of human retinal cells with bovine aortic endothelial cells in the NASA bioreactor.

@article{Dutt2003ThreedimensionalMO,
  title={Three-dimensional model of angiogenesis: coculture of human retinal cells with bovine aortic endothelial cells in the NASA bioreactor.},
  author={Kamla Dutt and Gary Sanford and Sandra Harris-Hooker and Lawrence A. Brako and Ravindra Kumar and Angela E. Sroufe and Caroline Melhado},
  journal={Tissue engineering},
  year={2003},
  volume={9 5},
  pages={
          893-908
        }
}
Ocular angiogenesis is the leading cause of blindness and is associated with diabetic retinopathy and age-related macular degeneration. We describe, in this report, our preliminary studies using a horizontally rotating bioreactor (HRB), developed by the National Aeronautics and Space Administration (NASA), to explore growth and differentiation-associated events in the early phase of ocular angiogenesis. Human retinal (HRet) cells and bovine endothelial cells (ECs) were cocultured on laminin… CONTINUE READING