Three-dimensional model of a human interferon-alpha consensus sequence.

  title={Three-dimensional model of a human interferon-alpha consensus sequence.},
  author={Angela Korn and David R. Rose and Eleanor N Fish},
  journal={Journal of interferon research},
  volume={14 1},
A computer-built, three-dimensional, atomic-level model for human interferon-alpha (IFN-alpha) was constructed. This model was prepared using the primary amino acid sequence of consensus IFN-alpha (IFN-alpha Con1) and the alpha-carbon Cartesian coordinates of murine IFN-beta as a homolog guide to the model building. In agreement with an earlier report from this laboratory, the two domains 29-35 and 123-140 are in close spatial proximity in this model, and may constitute a receptor recognition… CONTINUE READING