Three-dimensional microchannels in biodegradable polymeric films for control orientation and phenotype of vascular smooth muscle cells.

@article{Shen2006ThreedimensionalMI,
  title={Three-dimensional microchannels in biodegradable polymeric films for control orientation and phenotype of vascular smooth muscle cells.},
  author={Jin Ye Shen and Mary B. Chan-Park and Bin He and Ai Ping Zhu and Xiao Guang Zhu and Roger W. Beuerman and Er Bin Yang and William C W Chen and Vincent Chan},
  journal={Tissue engineering},
  year={2006},
  volume={12 8},
  pages={2229-40}
}
The poor mechanical strength and vasoactivity of current small-diameter tissue engineered blood vessels (TEBVs) remain unsolved problems. Given the plasticity of smooth muscle cells (SMCs), 1 of the main limitations of current scaffolding techniques is the difficulty in controlling SMC phenotype shifts in vitro. A synthetic phenotype allows the cells to rapidly proliferate and produce extracellular matrix (ECM), whereas a shift to contractile phenotype with organized ECM ultimately provides a… CONTINUE READING
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…