Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin

@article{Marshall2008ThreedimensionalLO,
  title={Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin},
  author={Owen J. Marshall and Alan T. Marshall and K. H. Andy Choo},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={1193 - 1202}
}
The histone H3 variant centromere protein A (CENP-A) is central to centromere formation throughout eukaryotes. A long-standing question in centromere biology has been the organization of CENP-A at the centromere and its implications for the structure of centromeric chromatin. In this study, we describe the three-dimensional localization of CENP-A at the inner kinetochore plate through serial-section transmission electron microscopy of human mitotic chromosomes. At the kinetochores of normal… CONTINUE READING
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