Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury

@article{Luo2013ThreedimensionalEO,
  title={Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury},
  author={Xueting Luo and Yadira Salgueiro and Samuel R. Beckerman and Vance P. Lemmon and Kevin Kiwon Park},
  journal={Experimental Neurology},
  year={2013},
  volume={247},
  pages={653-662}
}

• Xueting Luo, Yadira Salgueiro, +2 authors Kevin Kiwon Park
• Published 2013 in Experimental Neurology
• DOI:10.1016/j.expneurol.2013.03.001

Injured retinal ganglion cell (RGC) axons do not regenerate spontaneously, causing loss of vision in glaucoma and after trauma. Recent studies have identified several strategies that induce long distance regeneration in the optic nerve. Thus, a pressing question now is whether regenerating RGC axons can find their appropriate targets. Traditional methods of assessing RGC axon regeneration use histological sectioning. However, tissue sections provide fragmentary information about axonal… CONTINUE READING

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