Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.

@article{Dan2007ThreedimensionalDO,
  title={Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.},
  author={P. Dan and Eric Lin and Jingbo Huang and P. Biln and G. Tibbits},
  journal={Biophysical journal},
  year={2007},
  volume={93 7},
  pages={
          2504-18
        }
}
Mechanisms of cardiac excitation-contraction coupling in neonates are still not clearly defined. Previous work in neonates shows reverse-mode Na(+)-Ca(2+) exchange to be the primary route of Ca(2+) entry during systole and the neonatal sarcoplasmic reticulum to have similar capability as that of adult in storing and releasing Ca(2+). We investigated Na(+)-Ca(2+) exchanger (NCX) and ryanodine receptor (RyR) distribution in developing ventricular myocytes using immunofluorescence, confocal… Expand
48 Citations
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