Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations.

@article{Taberlay2016ThreedimensionalDO,
  title={Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations.},
  author={Phillippa C. Taberlay and Joanna Achinger-Kawecka and Aaron T. L. Lun and Fabian A. Buske and Kenneth Sabir and Cathryn M. Gould and Elena Zotenko and Saul A Bert and Katherine A Giles and Denis C. Bauer and Gordon K Smyth and Clare Stirzaker and Se{\'a}n I. O'Donoghue and Susan J. Clark},
  journal={Genome research},
  year={2016},
  volume={26 6},
  pages={719-31}
}
A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type-specific gene expression profiles. Here, we performed Hi-C chromosome conformation capture sequencing to investigate how three-dimensional chromatin organization is disrupted in the context of copy-number variation, long-range epigenetic remodeling, and atypical gene expression programs in prostate… CONTINUE READING

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