Three-dimensional context regulation of metastasis

  title={Three-dimensional context regulation of metastasis},
  author={Janine T Erler and Valerie M Weaver},
  journal={Clinical & Experimental Metastasis},
Tumor progression ensues within a three-dimensional microenvironment that consists of cellular and non-cellular components. The extracellular matrix (ECM) and hypoxia are two non-cellular components that potently influence metastasis. ECM remodeling and collagen cross-linking stiffen the tissue stroma to promote transformation, tumor growth, motility and invasion, enhance cancer cell survival, enable metastatic dissemination, and facilitate the establishment of tumor cells at distant sites… CONTINUE READING

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