Three-dimensional colocalization analysis of plasma-derived apolipoprotein B with amyloid plaques in APP/PS1 transgenic mice

@article{Takechi2009ThreedimensionalCA,
  title={Three-dimensional colocalization analysis of plasma-derived apolipoprotein B with amyloid plaques in APP/PS1 transgenic mice},
  author={Ryusuke Takechi and Susan Galloway and Menuka Pallebage-Gamarallage and Cheryl L Wellington and Russell D. Johnsen and John Charles Mamo},
  journal={Histochemistry and Cell Biology},
  year={2009},
  volume={131},
  pages={661-666}
}
Parenchymal accumulation of amyloid-beta (Aβ) is a hallmark pathological feature of Alzheimer’s disease. An emerging hypothesis is that blood-to-brain delivery of Aβ may increase with compromised blood–brain barrier integrity. In plasma, substantial Aβ is associated with triglyceride-rich lipoproteins (TRLs) secreted by the liver and intestine. Utilizing apolipoprotein B as an exclusive marker of hepatic and intestinal TRLs, here we show utilizing an highly sensitive 3-dimensional immuno… CONTINUE READING

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