Three-dimensional chromatin distribution in neuroblastoma nuclei shown by confocal scanning laser microscopy

@article{Brakenhoff1985ThreedimensionalCD,
  title={Three-dimensional chromatin distribution in neuroblastoma nuclei shown by confocal scanning laser microscopy},
  author={G. J. Brakenhoff and H. T. M. van der Voort and Edwin A. van Spronsen and Wilbert A. M. Linnemans and Nanne Nanninga},
  journal={Nature},
  year={1985},
  volume={317},
  pages={748-749}
}
The relationship between cell shape and function has long been of interest1–9. However, although the behaviour of the cytoskeleton during the cell cycle has been studied extensively10–12 variations in the shape and three-dimensional substructure of the nucleus are less well documented. The spatial distribution of chromatin has previously been studied by a mathematical analysis of the optical densities of stained nuclei13–15, allowing an indirect derivation of the three-dimensional distribution… CONTINUE READING