Three-dimensional architecture of the skeletal muscle ryanodine receptor.

  title={Three-dimensional architecture of the skeletal muscle ryanodine receptor.},
  author={Terence C Wagenknecht and Michael Radermacher},
  journal={FEBS letters},
  volume={369 1},
Recent advances in determining the three-dimensional architecture of the skeletal muscle ryanodine receptor/calcium release channel (RyR) by cryo-electron microscopy and three-dimensional reconstruction are discussed. The tetrameric receptor is characterized by a large 4-fold symmetric cytoplasmic assembly that consists of many domains separated by solvent-containing crevices and holes. Experimental evidence suggests that at least one regulatory ligand, calmodulin, binds to sites on the… CONTINUE READING

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