Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis

@article{Liu1999ThreeDM,
  title={Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis},
  author={C-L. Liu and Simon Edwards and Qiyong Gong and Neil Roberts and Lance D. Blumhardt},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={1999},
  volume={66},
  pages={323 - 330}
}
OBJECTIVE The association between brain atrophy and permanent functional deficits in multiple sclerosis and the temporal relation between atrophy and the clinical disease course have seldom been investigated. This study aims to determine the amount of infratentorial and supratentorial atrophy in patients by comparison with healthy controls, to establish the relation between atrophy and disability, and to derive the rates of volume loss in individual patients from their estimated disease… 
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