Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis

  title={Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis},
  author={C-L. Liu and Simon Edwards and Qiyong Gong and Neil Roberts and Lance D. Blumhardt},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  pages={323 - 330}
OBJECTIVE The association between brain atrophy and permanent functional deficits in multiple sclerosis and the temporal relation between atrophy and the clinical disease course have seldom been investigated. This study aims to determine the amount of infratentorial and supratentorial atrophy in patients by comparison with healthy controls, to establish the relation between atrophy and disability, and to derive the rates of volume loss in individual patients from their estimated disease… 
Determination of Brain Volumes Using Quantitative MR Imaging in Patients with Multiple Sclerosis
MRI-estimated cerebrum volumes may be help to evaluate patients' clinical status and provide a simple index to assess the efficiency of therapy.
resonance imaging, cerebral atrophy, and disability in multiple sclerosis
This study shows for the first time that quantitative MRI measures of di V usion correlate with clinical variables (disability, disease duration) and cerebral atrophy in multiple sclerosis.
Progressive cerebral atrophy in MS
Registration-based measurements are sensitive and reproducible, allowing progressive atrophy to be detected within 1 year and may have potential as a marker of progression in monitoring therapeutic trials.
Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients
Brain atrophy measurement and change in BPF was correlated with the changes in disability scores from the end of the phase III trial to the follow-up exam, suggesting that brain atrophy may be a useful and clinically relevant marker of disease progression in relapsing-remitting MS.
Normalized regional brain atrophy measurements in multiple sclerosis
There is still a controversy regarding the best regional brain atrophy measurements in multiple sclerosis (MS) studies. The aim of this study was to establish whether, in a cross-sectional study, the
Frontal parenchymal atrophy measures in multiple sclerosis
Data suggest that RBPF is a reproducible and sensitive method for measuring frontal parenchymal atrophy, and should be preferred to absolute measures in future studies that correlate neuropsychological performances and brain atrophy measures in patients with MS.
Brain atrophy and lesion load in a large population of patients with multiple sclerosis
Patients with multiple sclerosis have significant atrophy of both white matter (WM) and gray matter (GM), and GM atrophy is the most significant MRI variable in determining the final disability.
C erebral atrophy and disability in relapsing-remitting and secondary progressive multiple sclerosis over four years
This study demonstrated an association between measures of cerebral atrophy and worsening disability and provides evidence that brain atrophy can be detected early in the disease course and central white matter atrophy as reflected by ventricle enlargement appears to be a continuous process.


Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis.
Using formalin-fixed brains of eight multiple sclerosis patients and eight age-matched controls, the relationship between demyelinating lesion load in three volumes of the cerebral white matter and the loss of axons in NAWM of the corresponding three projection regions in the corpus callosum is examined.
Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression.
Given its reproducibility, the magnitude of the change detected and the strong correlation with disability, this new technique should prove to be a sensitive measure of progressive neurological deterioration and could be readily incorporated into imaging protocols aimed at monitoring therapy.
Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms.
In relapsing-remitting and secondarygressive multiple sclerosis both brain and spinal cord MRI may provide a tool for monitoring patients, while in primary progressive multiple sclerosis the clinicoradiological correlation is weak for brain imaging.
Imaging axonal damage of normal-appearing white matter in multiple sclerosis.
Results add to data suggesting that axonal damage or loss may be responsible for functional impairments in multiple sclerosis, and may be of particular significance for understanding chronic disability in this disease.
MR of the spinal cord in multiple sclerosis: relation to clinical subtype and disability.
The MR appearance of the spinal cord differs among clinical subgroups of MS, with diffuse abnormality associated with a progressive clinical course and greater disability than did patients without diffuse abnormalities.
Spinal cord atrophy and disability in MS
It is demonstrated, for the first time, that it is possible to measure changes in cord cross-sectional area over time, and the serial measurement of spinal cord atrophy may make an important contribution to the evaluation of therapeutic efficacy, especially in primary progressive disease.
Measures of brain and spinal cord atrophy in multiple sclerosis.
  • N. Losseff, D. Miller
  • Psychology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1998
The measurement of atrophy now provides objective markers by which to evaluate putative treatment aimed at preventing disability in multiple sclerosis.
Functional and magnetic resonance imaging correlates of callosal involvement in multiple sclerosis.
Performance on each functional task was predominantly associated with atrophy of one part of the callosum, namely left-ear dichotic suppression with the posterior callosal region, alternate finger tapping with the anterior region, and cross-localization with midanterior and posterior regions.
MRI dynamics of brain and spinal cord in progressive multiple sclerosis.
Although the detection of new lesions by frequent cord imaging using current technology has little role in the monitoring of disease activity in progressive multiple sclerosis, the serial measurement of cord cross sectional area may be important.
1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis
The hypothesis that axonal loss is important in the development of disability in multiple sclerosis is supported and evidence for axonal Loss in normal appearing white matter in patients with primary progressive disease is provided.