Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications.

  title={Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications.},
  author={Megan A Pattison and Susan Wurster and Thomas Webster and Karen M. Haberstroh},
  volume={26 15},
In total, approximately 400 million people worldwide suffer from urinary bladder cancer (Nat Biotechnol 17 (1999) 149). When radical cysectomy is required as treatment, a replacement material is clearly necessitated. For this purpose, three-dimensional poly(lactic-co-glycolic acid) (PLGA) scaffolds were constructed using solvent casting and salt leaching processes. These scaffolds were manipulated to possess nano-dimensional surface features by soaking in sodium hydroxide at select… CONTINUE READING
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