Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.

@article{Conway2000ThreeDE,
  title={Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.},
  author={Edward M Conway and Saskia Pollefeyt and Jacqueline Cornelissen and I DeBaere and Marta Steiner-Mosonyi and Karolyn Ong and Mathijs Baens and D{\'e}sir{\'e} Collen and Andre C. Schuh},
  journal={Blood},
  year={2000},
  volume={95 4},
  pages={1435-42}
}
Survivin is a member of the inhibitor of apoptosis protein (IAP) family that is believed to play a role in oncogenesis. To elucidate further its physiologic role(s), we have characterized the murine survivin gene and complementary DNA (cDNA). The structural organization of the survivin gene, located on chromosome 11E2, is similar to that of its human counterpart, both containing 4 exons. Surprisingly, 3 full-length murine survivin cDNA clones were isolated, predicting the existence of 3… CONTINUE READING

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