Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus.

@article{Tsuda2004ThreeDN,
  title={Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus.},
  author={Yasuhiro Tsuda and Hitoshi Takahashi and Makiko Kobayashi and Toshiaki Hanafusa and David N . Herndon and Fujio Suzuki},
  journal={Immunity},
  year={2004},
  volume={21 2},
  pages={215-26}
}
Neutrophils (PMN) have been described as critical effector cells in the host's antibacterial innate immunities. However, the classification of murine PMNs remains unclear. Here, we show that in addition to normal PMN (PMN-N), there are at least two distinct subsets of PMNs (PMN-I and PMN-II) distinguished as follows: (1) cytokine and chemokine production (PMN-I, IL-12/CCL3; PMN-II, IL-10/CCL2; PMN-N, no cytokine/chemokine production), (2) macrophage activation (PMN-I, classically activated… CONTINUE READING

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