Three decades of Wnts: a personal perspective on how a scientific field developed.

@article{Nusse2012ThreeDO,
  title={Three decades of Wnts: a personal perspective on how a scientific field developed.},
  author={Roeland Nusse and H. E. Varmus},
  journal={The EMBO journal},
  year={2012},
  volume={31 12},
  pages={2670-84}
}
Wnt genes and components of Wnt signalling pathways have been implicated in a wide spectrum of important biological phenomena, ranging from early organismal development to cell behaviours to several diseases, especially cancers. Emergence of the field of Wnt signalling can be largely traced back to the discovery of the first mammalian Wnt gene in 1982. In this essay, we mark the thirtieth anniversary of that discovery by describing some of the critical scientific developments that led to the… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 9 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 142 extracted citations

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

Current pharmaceutical design • 2012
View 8 Excerpts
Highly Influenced

Hippocampal Wnt Signaling: Memory Regulation and Hormone Interactions.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry • 2016
View 4 Excerpts
Highly Influenced

Wnt signaling in the nervous system and in Alzheimer's disease.

Journal of molecular cell biology • 2014
View 6 Excerpts
Highly Influenced

Signal integration in TGF-β, WNT, and Hippo pathways

F1000prime reports • 2013
View 11 Excerpts
Highly Influenced

Targeting Wnt-Frizzled signaling in cardiovascular diseases

Molecular Biology Reports • 2013
View 4 Excerpts
Highly Influenced

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

Journal of Neuroimmune Pharmacology • 2012
View 9 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 173 references

Functions and origins of retroviral

JM Bishop, H Varmus
1985
View 5 Excerpts
Highly Influenced

The evolution of the Wnt pathway.

Cold Spring Harbor perspectives in biology • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…