Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane

@inproceedings{Legan2014ThreeDM,
  title={Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane},
  author={P. Kevin Legan and Richard J Goodyear and Mat{\'i}as Mor{\'i}n and Angeles Menc{\'i}a and Hilary Pollard and Leticia Olavarrieta and Julia Korchagina and Silvia Modamio-Hoybjor and F A A A A I Mayo and Felipe Moreno and Miguel-Angel Moreno-Pelayo and Guy P Richardson},
  booktitle={Human molecular genetics},
  year={2014}
}
Tecta is a modular, non-collagenous protein of the tectorial membrane (TM), an extracellular matrix of the cochlea essential for normal hearing. Missense mutations in Tecta cause dominant forms of non-syndromic deafness and a genotype-phenotype correlation has been reported in humans, with mutations in different Tecta domains causing mid- or high-frequency hearing impairments that are either stable or progressive. Three mutant mice were created as models for human Tecta mutations; the Tecta… CONTINUE READING
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Loss of the mammal-specific tectorial membrane component CEA cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies

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