Three consecutive primary malignancies in one patient during childhood.


Patients with a primary immunodeficiency syndrome have an increased risk of developing a malignancy. Lymphoreticular malignancies are the most common malignancies in these patients. Patients with ataxia telangiectasia (AT) also appear to be at a high risk for the development of nonlymphoid tumors--in particular, carcinomas of the gastrointestinal tract and central nervous system tumors. We describe a child with an immunodeficiency and slight neurological manifestations. During childhood she developed three consecutive primary malignancies.

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@article{GrootLoonen1988ThreeCP, title={Three consecutive primary malignancies in one patient during childhood.}, author={Jacqueline J Groot-Loonen and R. M. Slater and J. A. J. M. Taminiau and Paul Antoine Vo{\^u}te}, journal={Pediatric hematology and oncology}, year={1988}, volume={5 4}, pages={287-92} }