Three complementation groups in Cockayne syndrome.

  title={Three complementation groups in Cockayne syndrome.},
  author={A. R. Lehmann},
  journal={Mutation research},
  volume={106 2},
After 16 Jm-2 of UV-irradiation non-dividing normal cells recover normal rates of RNA synthesis within 24 h, whereas in cells from donors with Cockayne syndrome (CS) the rate of RNA synthesis gradually declines. Cultures of a mixed population from 2 CS donors were fused with polyethylene glycol; subsequently they were UV-irradiated and RNA synthesis was measured autoradiographically in mono-, bi-, and multinuclear cells. Genetic complementation was indicated by high levels of RNA synthesis in… CONTINUE READING