Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.

  title={Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.},
  author={Gustav J. Strijkers and Sjoerd Hak and Maarten B Kok and Charles S. Springer and Klaas Nicolay},
  journal={Magnetic resonance in medicine},
  volume={61 5},
The goal of this work was to elaborate a model describing the effective longitudinal relaxation rate constant R(1) for (1)H(2)O in three cellular compartments experiencing possible equilibrium water exchange, and to apply this model to explain the effective R(1) dependence on the overall concentration of a cell-internalized Gd(3+)-based contrast agent (CA). The model voxel comprises three compartments representing extracellular, cytoplasmic, and vesicular (e.g., endosomal, lysosomal… CONTINUE READING


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