Three biscembranoids and their monomeric counterpart cembranoid, a biogenetic Diels-Alder precursor, from the soft coral Sarcophyton elegans.

@article{Bishara2007ThreeBA,
  title={Three biscembranoids and their monomeric counterpart cembranoid, a biogenetic Diels-Alder precursor, from the soft coral Sarcophyton elegans.},
  author={Ashgan Bishara and Amira Rudi and Yehuda Benayahu and Yoel Kashman},
  journal={Journal of natural products},
  year={2007},
  volume={70 12},
  pages={
          1951-4
        }
}
Two new cembranoids, methyl tetrahydrosarcoate ( 1) and methyl tetrahydroisosarcoate ( 2), were isolated from the soft coral Sarcophyton elegans, collected at Kitangambwe Kenya, together with four biscembranoids, the known nyalolide ( 3) and the unprecedented desacetylnyalolide ( 4), diepoxynyalolide ( 5), and dioxanyalolide ( 6). The structures and relative stereochemistry of the compounds were elucidated by interpretation of MS, 1D NMR, COSY, HSQC, HMBC, and NOESY experiments. Compound 1 is… 
Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans
TLDR
Two novel biscembranoids, sarelengans A and B (1 and 2), and five new cembranoid, saRELengans C–G (3–7) were isolated from the South China Sea soft coral Sarcophyton elegans, and their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction.
New pyranosyl cembranoid diterpenes from Sarcophyton trocheliophorum
TLDR
The isolation and structural elucidation of further two new pyrane-based cembranoid diterpenes from Sarcophyton trocheliophorum are described, with sarcophine displaying the highest affinity towards both crystal structures.
Biscembranoids formed from an α,β-unsaturated γ-lactone ring as a dienophile: structure revision and establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra.
TLDR
Four new biscembranoids were isolated from the Hainan soft coral Sarcophyton latum by detailed analysis of spectroscopic data and by comparison with reported data of related derivatives, leading to the structure revision of co-occurring bislatumlides A (5) and B (6) at the C-21 configuration.
Bioactive Capnosanes and Cembranes from the Soft Coral Klyxum flaccidum
TLDR
The isolated diterpenoids isolated from the genus Klyxum exhibited anti-inflammatory activity through suppression of superoxide anion generation and elastase release in the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-stimulated human neutrophils and exhibited cytotoxicity toward the tested cancer cells.
Structural revision of methyl tortuoate D, a bis-cembranoid from Hainan Sarcophyton tortuosum and its absolute stereochemistry
TLDR
The structure of methyl tortuoate D, together with five other known related bis-cembranoids, was isolated from Hainan soft coral Sarcophyton tortuosum and was corrected as 1 by an extensive analysis of its one-dimensional and two-dimensional nuclear magnetic resonance data.
Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi
TLDR
Five new polyoxygenated cembranoids were obtained from the soft coral Sarcophyton ehrenbergi and showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 μM.
Sarcophytolides G–L, New Biscembranoids from the Soft Coral Sarcophyton elegans
Six new biscembranoids, namely, sarcophytolides G–L (1–6, resp.), together with six known analogs, were isolated from a marine soft coral Sarcophyton elegans. The structures of the new compounds were
Lobophytones U – Z1, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum
TLDR
The structures of the new compounds were elucidated by 1D‐ and 2D‐NMR spectroscopic analysis in association with MS and IR data and showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
Lobophytones H-N, Biscembranoids from the Chinese soft coral Lobophytum pauciflorum.
TLDR
Seven new biscembranoids, named lobophytones H-N (1-7), were isolated from a Chinese soft coral by interpretation of 1D- and 2D-NMR spectroscopic data and cytotoxicity of mouse peritoneal macrophage, and antibacterial activities.
Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
TLDR
Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
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