Three alkylation methods for the determination of indometacin in plasma by electron capture gas chromatography.

  • A Arbin
  • Published 1977 in Journal of chromatography

Abstract

The following alkylation methods for the determination of indometacin in plasma by electron capture gas chromatography are compared: 1, alkylation with diazopropane; 2, extractive alkylation; 3, alkylation by a solid-liquid phase transfer catalysed process. The drug in plasma at pH 4.0 is initially extracted with heptane containing 5% n-pentanol. The methyl… (More)

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Cite this paper

@article{Arbin1977ThreeAM, title={Three alkylation methods for the determination of indometacin in plasma by electron capture gas chromatography.}, author={A Arbin}, journal={Journal of chromatography}, year={1977}, volume={144 1}, pages={85-92} }