Three-Step Model for Polarized Sorting of KIF17 into Dendrites

  title={Three-Step Model for Polarized Sorting of KIF17 into Dendrites},
  author={M. Franker and M. R. Silva and R. Tas and Elena Tortosa and Yujie Cao and C. P. Frias and A. F. Janssen and Phebe S. Wulf and L. Kapitein and C. Hoogenraad},
  journal={Current Biology},
  • M. Franker, M. R. Silva, +7 authors C. Hoogenraad
  • Published 2016
  • Biology, Medicine
  • Current Biology
  • Kinesin and dynein motors drive bidirectional cargo transport along microtubules and have a critical role in polarized cargo trafficking in neurons [1, 2]. The kinesin-2 family protein KIF17 is a dendrite-specific motor protein and has been shown to interact with several dendritic cargoes [3-7]. However, the mechanism underlying the dendritic targeting of KIF17 remains poorly understood [8-11]. Using live-cell imaging combined with inducible trafficking assays to directly probe KIF17 motor… CONTINUE READING
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