Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.

@article{Ramanathan2001ThreeRP,
  title={Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.},
  author={Yamunadevi V Ramanathan and S M Rajpara and Syed M. S. Reza and Emma Frances Lees and Stewart Shuman and Michael B. Mathews and Tsafi Pe'ery},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 14},
  pages={
          10913-20
        }
}
CDK7, CDK8, and CDK9 are cyclin-dependent kinases (CDKs) that phosphorylate the C-terminal domain (CTD) of RNA polymerase II. They have distinct functions in transcription. Because the three CDKs target only serine 5 in the heptad repeat of model CTD substrates containing various numbers of repeats, we tested the hypothesis that the kinases differ in their ability to phosphorylate CTD heptad arrays. Our data show that the kinases display different preferences for phosphorylating individual… CONTINUE READING
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