Three New Pigment Protein Tyrosine Phosphatases Inhibitors from the Insect Parasite Fungus Cordyceps gracilioides: Terreusinone A, Pinophilin C and Cryptosporioptide A

@article{Wei2015ThreeNP,
  title={Three New Pigment Protein Tyrosine Phosphatases Inhibitors from the Insect Parasite Fungus Cordyceps gracilioides: Terreusinone A, Pinophilin C and Cryptosporioptide A},
  author={Pei-Yao Wei and Linxia Liu and T. Liu and Chuan Chen and Du-Qiang Luo and Bao-zhong Shi},
  journal={Molecules},
  year={2015},
  volume={20},
  pages={5825 - 5834}
}
  • Pei-Yao Wei, Linxia Liu, +3 authors Bao-zhong Shi
  • Published 2015
  • Biology, Medicine
  • Molecules
  • Three new pigment compounds—terreusinone A (1), pinophilin C (2) and cryptosporioptide A (3) were isolated from a solid culture of Cordyceps gracilioides. The structures of these compounds were determined by extensive spectroscopic analysis including HRESIMS, 1D- and 2D-NMR. The structure of terreusinone A (1) was further confirmed by single-crystal X-ray crystallographic diffraction analysis. In an in vitro activity assay, 1, 2 and 3 exhibited high inhibitory activity against PTP1B, SHP2… CONTINUE READING
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