Three Mechanisms Assemble Central Nervous System Nodes of Ranvier

  title={Three Mechanisms Assemble Central Nervous System Nodes of Ranvier},
  author={Keiichiro Susuki and Kae-Jiun Chang and Daniel R Zollinger and Yanhong Liu and Yasuhiro Ogawa and Yael Eshed-Eisenbach and Mar{\'i}a Teresa Dours-Zimmermann and Juan A Oses-Prieto and Alma L. Burlingame and Constanze I. Seidenbecher and Dieter Robert Zimmermann and Toshitaka Oohashi and Elior Peles and Matthew N Rasband},
Rapid action potential propagation in myelinated axons requires Na⁺ channel clustering at nodes of Ranvier. However, the mechanism of clustering at CNS nodes remains poorly understood. Here, we show that the assembly of nodes of Ranvier in the CNS involves three mechanisms: a glia-derived extracellular matrix (ECM) complex containing proteoglycans and adhesion molecules that cluster NF186, paranodal axoglial junctions that function as barriers to restrict the position of nodal proteins, and… CONTINUE READING
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