Three Distinct Glutamate Decarboxylase Genes in Vertebrates

@inproceedings{Grone2016ThreeDG,
  title={Three Distinct Glutamate Decarboxylase Genes in Vertebrates},
  author={Brian P Grone and Karen P Maruska},
  booktitle={Scientific reports},
  year={2016}
}
Gamma-aminobutyric acid (GABA) is a widely conserved signaling molecule that in animals has been adapted as a neurotransmitter. GABA is synthesized from the amino acid glutamate by the action of glutamate decarboxylases (GADs). Two vertebrate genes, GAD1 and GAD2, encode distinct GAD proteins: GAD67 and GAD65, respectively. We have identified a third vertebrate GAD gene, GAD3. This gene is conserved in fishes as well as tetrapods. We analyzed protein sequence, gene structure, synteny, and… CONTINUE READING
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