Three-Dimensional Structure of the Complexin/SNARE Complex

@article{Chen2002ThreeDimensionalSO,
  title={Three-Dimensional Structure of the Complexin/SNARE Complex},
  author={Xiaocheng Chen and Diana R. Tomchick and Evguenii Kovrigin and Demet Araç and Mischa Machius and Thomas C. S{\"u}dhof and Josep Rizo},
  journal={Neuron},
  year={2002},
  volume={33},
  pages={397-409}
}
During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca(2+)-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an… Expand
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TLDR
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TLDR
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TLDR
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