Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli

@article{Yamagata1996ThreeDimensionalSO,
  title={Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli},
  author={Yuriko Yamagata and Masato Kato and Kyoko Odawara and Yoshiteru Tokuno and Yoko Nakashima and Nobuko Matsushima and Kohei Yasumura and Ken-ichi Tomita and Kenji Ihara and Yoshimitsu Fujii and Yusaku Nakabeppu and Mutsuo Sekiguchi and Satoshi Fujii},
  journal={Cell},
  year={1996},
  volume={86},
  pages={311-319}
}
The three-dimensional structure of Escherichia coli 3-methyladenine DNA glycosylase II, which removes numerous alkylated bases from DNA, was solved at 2.3 A resolution. The enzyme consists of three domains: one alpha + beta fold domain with a similarity to one-half of the eukaryotic TATA box-binding protein, and two all alpha-helical domains similar to those of Escherichia coli endonuclease III with combined N-glycosylase/abasic lyase activity. Mutagenesis and model-building studies suggest… CONTINUE READING
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