Three-Dimensional Structure and Composition of CA3→CA1 Axons in Rat Hippocampal Slices: Implications for Presynaptic Connectivity and Compartmentalization

@article{Shepherd1998ThreeDimensionalSA,
  title={Three-Dimensional Structure and Composition of CA3→CA1 Axons in Rat Hippocampal Slices: Implications for Presynaptic Connectivity and Compartmentalization},
  author={Gordon M. G. Shepherd and Kristen M. Harris},
  journal={The Journal of Neuroscience},
  year={1998},
  volume={18},
  pages={8300 - 8310}
}
Physiological studies of CA3→CA1 synaptic transmission and plasticity have revealed both pre- and postsynaptic effects. Understanding the extent to which individual presynaptic axonal boutons could provide local compartments for control of synaptic efficacy and microconnectivity requires knowledge of their three-dimensional morphology and composition. In hippocampal slices, serial electron microscopy was used to examine a nearly homogeneous population of CA3→CA1 axons in the middle of stratum… 

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