Three-Dimensional Stochastic Off-Lattice Model of Binding Chemistry in Crowded Environments

  title={Three-Dimensional Stochastic Off-Lattice Model of Binding Chemistry in Crowded Environments},
  author={Byoungkoo Lee and Philip LeDuc and Russell Schwartz},
  booktitle={PloS one},
Molecular crowding is one of the characteristic features of the intracellular environment, defined by a dense mixture of varying kinds of proteins and other molecules. Interaction with these molecules significantly alters the rates and equilibria of chemical reactions in the crowded environment. Numerous fundamental activities of a living cell are strongly influenced by the crowding effect, such as protein folding, protein assembly and disassembly, enzyme activity, and signal transduction… CONTINUE READING


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Highly Influential
5 Excerpts

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