Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold.

  title={Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold.},
  author={Seng Han Lim and Samuel Ming Yuan Chia and Lifeng Kang and Kevin Yi-Lwern Yap},
  journal={Journal of pharmaceutical sciences},
  volume={105 7},
Carbamazepine is the first-line anti-epileptic drug for focal seizures and generalized tonic-clonic seizures. Although sustained-release formulations exist, an initial burst of drug release is still present and this results in side effects. Zero-order release formulations reduce fluctuations in serum drug concentrations, thereby reducing side effects. Three-dimensional printing can potentially fabricate zero-order release formulations with complex geometries. 3D printed scaffolds with varying… CONTINUE READING
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