Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow

@inproceedings{DereliKorkut2014ThreeDM,
  title={Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow},
  author={Zeynep Dereli-Korkut and Huseyin Dogus Akaydin and A. H. Rezwanuddin Ahmed and Xuejun Jiang and Sihong Wang},
  booktitle={Analytical chemistry},
  year={2014}
}
  • Zeynep Dereli-Korkut, Huseyin Dogus Akaydin, +2 authors Sihong Wang
  • Published in Analytical chemistry 2014
  • Chemistry, Medicine
  • Currently, there are no reliable ex vivo models that predict anticancer drug responses in human tumors accurately. A comprehensive method of mimicking a 3D microenvironment to study effects of anticancer drugs on specific cancer types is essential. Here, we report the development of a three-dimensional microfluidic cell array (3D μFCA), which reconstructs a 3D tumor microenvironment with cancer cells and microvascular endothelial cells. To mimic the in vivo spatial relationship between… CONTINUE READING

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