Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development

@inproceedings{Ekert2014ThreeDimensionalLT,
  title={Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development},
  author={Jason E. Ekert and Kjell Johnson and Brandy Strake and Jose R. Pardinas and Stephen W. Jarantow and Robert A. Perkinson and David C. Colter},
  booktitle={PloS one},
  year={2014}
}
Three-dimensional (3D) cell culture is gaining acceptance in response to the need for cellular models that better mimic physiologic tissues. Spheroids are one such 3D model where clusters of cells will undergo self-assembly to form viable, 3D tumor-like structures. However, to date little is known about how spheroid biology compares to that of the more traditional and widely utilized 2D monolayer cultures. Therefore, the goal of this study was to characterize the phenotypic and functional… CONTINUE READING
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Effective Determination of Cellular Viability in Microtissue Spheroids

  • W Moritz
  • Promega Corporation
  • 2011
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